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KMID : 0606920110190010033
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Biomolecules & Therapeutics
2011 Volume.19 No. 1 p.33 ~ p.37
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Decursin from Angelica gigas Nakai Blocks hKv1.5 Channel
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Kwak Yong-Geun
Choi Bok-Hee
Kim Dae-Keun
Eun Jae-Soon
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Abstract
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Decursin was purifi ed from Angelica gigas Nakai, and its effects on the human Kv1.5 (hKv1.5) currents were recorded in mouse fi broblasts (Ltk? cells) by whole-cell patch-clamp technique. Decursin inhibited hKv1.5 current in a concentration-dependent manner, with an IC50 value of 2.7 μM at +60 mV. Decursin accelerated the inactivation kinetics of the hKv1.5 channel, and slowed the deactivation kinetics of the hKv1.5 current, resulting in a tail crossover phenomenon. Also, decursin inhibited the hKv1.5 current in a use-dependent manner. These results strongly suggest that decursin is a kind of open-channel blocker of the hKv1.5 channel.
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KEYWORD
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hKv1.5 channel blocker, Decursin, Angelica gigas Nakai
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